Correction to: Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes
نویسندگان
چکیده
منابع مشابه
Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric brain cancer with no effective therapy. Histological similarity of DIPG to supratentorial high-grade astrocytomas of adults has led to assumptions that these entities possess similar underlying molecular properties and therefore similar therapeutic responses to standard therapies. The failure of all clinical trials in the last 3...
متن کاملIntegrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are ref...
متن کاملMolecular genetic approaches and potential new therapeutic strategies for pediatric diffuse intrinsic pontine glioma.
Diffuse intrinsic pontine gliomas (DIPG) are tumors that diffusely involve the brainstem and appear almost exclusively during childhood and adolescence. This devastating cancer is the main cause of brain tumor–related death in children, with a median survival time of less than 1 year for the majority of affected patients. Because of the location, surgical resection is not an option for this dis...
متن کاملDiffusion Tensor Histogram Analysis of Pediatric Diffuse Intrinsic Pontine Glioma
PURPOSE To evaluate tumor structure in children with diffuse intrinsic pontine glioma (DIPG) using histogram analyses of mean diffusivity (MD), determine potential treatment and corticosteroid-related effects on MD, and monitor changes in MD distributions over time. MATERIALS AND METHODS DTI was performed on a 1.5T GE scanner. Regions of interest included the entire FLAIR-defined tumor. MD da...
متن کاملPotential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effec...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2020
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-020-02162-6